ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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BSE/TSE (Bovine Spongiform Encephalopathy/Transmissible Spongiform Encephalopathy)

Transmissible Spongiform Encephalopathies are a class of lethal diseases characterized by brain lesions. Examples of TSEs include scrapie in sheep and goats, BSE in cattle and Creutzfeldt-Jakob disease in humans. The appearance of a new variant of Creutzfeldt-Jakob disease has raised concerns regarding the risk of transmission of these diseases from medicines containing certain bovine-derived ingredients.

Publication Source: ISPE Baseline® Guide, Vol. 6: Biopharmaceutical Manufacturing Facilities

Publication Date: 2004

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