ISPE Glossary of Pharmaceutical and Biotechnology Terminology

Print this page         
Find Definition by Term and/or Language
Term Language (Optional)
Browse All Terms
Beginning With By Language
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z :: All English
Deutsch
Francais

Breakthrough

The first appearance in the effluent of an ion-exchange unit of unadsorbed components similar to those that deplete the activity of the resin bed. Breakthrough indicates that the resin is exhausted and needs to be regenerated.

Breakthrough

Passage of a substance through a bed, filter, or process designed to eliminate it. For ion exchange processes, the first signs are leakage of ions (in mixed beds, usually Silica) and the resultant increase in conductivity. For organic removal beds, usually small, volatile compounds (Trihalomethanes (THMs) are common in activated carbon).

Publication Source: ISPE Baseline® Guide, Vol. 4: Water and Steam Systems (Second Edition)

Publication Date: 2011

Do you have a term that should be included in the glossary?
Submit a term for review

My ISPE

  • Click to go to My Communities of Practice
  • Click to go to My Affiliate or Chapter
  • Click to go to My Profile
Click to go to the Member Gift