ISPE Glossary of Pharmaceutical and Biotechnology Terminology

Print this page         
Find Definition by Term and/or Language
Term Language (Optional)
Browse All Terms
Beginning With By Language
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z :: All English

DOP (Dioctyl Phthalate)

A non-dispersed test aerosol historically used to evaluate integrity of HEPA filters.

Publication Source: ISPE Baseline® Guide, Vol. 1: Bulk Pharmaceutical Chemicals
Publication Date: 1996

DOP (Dioctyl Phthalate)

A mono-dispersed test aerosol of sub-micron particles, generated to challenge (evaluate integrity) of HEPA filters for HVAC.

See also: Polyalphaolefin (PAO)

DOP (Dioctyl Phthalate)

Material used in the past to generate aerosols comprising particles in the 0.1 to 0.7 micron range (typically with an average size of 0.3 micron) used to test HEPA and ULPA filters. This chemical is believed to have carcinogenic properties and has been generally replaced by a mineral oil, e.g., Emery 3004/Durasyn 164, or Shell Ondina EL.

The smoke generated from this has very similar characteristics and the term DOP testing remains, although it is now understood to mean “Dispersed Oil Particulate”.

Publication Source: ISPE Good Practice Guide: Heating, Ventilation, and Air Conditioning (HVAC)

Publication Date: 2009

Do you have a term that should be included in the glossary?
Submit a term for review


  • Click to go to My Communities of Practice
  • Click to go to My Affiliate or Chapter
  • Click to go to My Profile
Click to go to the Member Gift