ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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DOP (Dioctyl Phthalate)

A non-dispersed test aerosol historically used to evaluate integrity of HEPA filters.

Publication Source: ISPE Baseline® Guide, Vol. 1: Bulk Pharmaceutical Chemicals
Publication Date: 1996

DOP (Dioctyl Phthalate)

A mono-dispersed test aerosol of sub-micron particles, generated to challenge (evaluate integrity) of HEPA filters for HVAC.

See also: Polyalphaolefin (PAO)

DOP (Dioctyl Phthalate)

Material used in the past to generate aerosols comprising particles in the 0.1 to 0.7 micron range (typically with an average size of 0.3 micron) used to test HEPA and ULPA filters. This chemical is believed to have carcinogenic properties and has been generally replaced by a mineral oil, e.g., Emery 3004/Durasyn 164, or Shell Ondina EL.

The smoke generated from this has very similar characteristics and the term DOP testing remains, although it is now understood to mean “Dispersed Oil Particulate”.

Publication Source: ISPE Good Practice Guide: Heating, Ventilation, and Air Conditioning (HVAC)

Publication Date: 2009

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