ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Double Helix (Duplex)

The structure of DNA as proposed by Watson and Crick. It consists of two right-handed helical polynucleotide chains coiled around the same axis. The two chains are anti-parallel with their 3rd. to 5th internucleotide phosphodiester bonds running in opposite directions. Under most conditions, the coiling of the chains is such that if the ends are held still, as in circular DNA or in a large chromosome, the chains cannot be separated except by cleavage of one of the strands.

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