ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Downstream

In molecular biology, the stretch of nucleotides of DNA that lie in the 3’ direction from the site of initiation of transcription, which is designated as +1 (remembering the convention that the sequence of a DNA molecule is written from the 5’ end to the 3’ end). Downstream nucleotides are marked with plus signs, e.g., +2, +10. Also, to the 3’ side of a particular gene or sequence of nucleotides.

Publication Source: Food and Agricultural Organization of the United Nations (FAO)
Publication Date: 1999

Downstream

In chemical engineering, those phases of a manufacturing process that follow the biotransformation stage. Usually refers to the recovery and purification of the product of a fermentation process.

Publication Source: Food and Agricultural Organization of the United Nations (FAO)
Publication Date: 1999

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