ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Cell wall debris (lipopolysaccharide) from Gram-negative bacteria.

Publication Source: ISPE Baseline® Guide, Vol. 3: Sterile Manufacturing Facilities (First Edition)

Publication Date: 2011


Pyrogens from certain Gram negative bacteria. Generally highly toxic Lipopolysaccharide-protein complexes (fat, linked sugars, and protein) from cell walls. A marker for these bacteria with a reputation for persistent contamination because they tend to adhere to surfaces.

Publication Source: ISPE Baseline® Guide, Vol. 4: Water and Steam Systems (Second Edition)

Publication Date: 2011

See also: Pyrogen

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