ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Expression

In biology, expression is the transcription of the genetic information contained in a gene by synthesis of a messenger RNA molecule and the subsequent synthesis of a protein.

In genetic engineering, expression is the production of a protein by introduction of a foreign gene into microorganisms or cell cultures.

Publication Source: ISPE Baseline® Guide, Vol. 6: Biopharmaceutical Manufacturing Facilities

Publication Date: 2004

See also: Transcription Translation

Expression

In genetics, manifestation of a characteristic that is specified by a gene. With hereditary disease, for example, a person can carry the gene for the disease but not actually have the disease. In this case, the gene is present but not expressed. In industrial biotechnology, the term is often used to mean the production of a protein by a gene that has been inserted into a new host organism.

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