ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Generally Regarded as Safe (GRAS)

Designation given to foods, drugs, and other materials that have been used for a considerable period of time and have a history of not causing illness to humans, even though extensive toxicity testing has not been conducted. More recently, certain host organisms for recombinant DNA experimentation have been given this status.

Publication Source: Food and Agricultural Organization of the United Nations (FAO)
Publication Date: 1999

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