ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Histocompatibility Complex; Histocompatibility System

The collection of genes coding for peptides present on the surface of nucleated cells; these peptides are responsible for the differences between genetically non-identical individuals that cause rejection of tissue grafts between such individuals. These peptides were originally called histocompatibility antigens. They are now called histoglobulins, reflecting their structural similarity to immunoglobulins.

Publication Source: Food and Agricultural Organization of the United Nations (FAO)
Publication Date: 1999

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