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A hybrid cell resulting from the fusion of a specific antibody producing spleen cell with a myeloma cell. The hybrid cell has the growth characteristics of the myeloma component and the antibody secreting characteristics of the spleen cell and will multiply to become a source of large quantities of pure, monoclonal antibody.
An immortalized cell line (usually derived by fusing B-lymphocyte cells with myeloma tumor cells) that secretes a desirable protein, typically a monoclonal antibody.
Publication Source: ISPE Baseline® Guide, Vol. 6: Biopharmaceutical Manufacturing Facilities
Publication Date: 2004
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