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Any process that destroys the ability of a specific microbiological agent or eukaryotic cell to self-replicate.
Elimination of the target material’s biological or chemical activity through chemicals, heat, or other means without necessarily eliminating the activity of other (non-targeted) material.
Publication Source: ISPE Baseline® Guide, Vol. 6: Biopharmaceutical Manufacturing Facilities
Publication Date: 2004
(ICH Q5A (R1)) Reduction of virus infectivity caused by chemical or physical modification
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