ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Any process that destroys the ability of a specific microbiological agent or eukaryotic cell to self-replicate.


Elimination of the target material’s biological or chemical activity through chemicals, heat, or other means without necessarily eliminating the activity of other (non-targeted) material.

Publication Source: ISPE Baseline® Guide, Vol. 6: Biopharmaceutical Manufacturing Facilities

Publication Date: 2004


(ICH Q5A (R1)) Reduction of virus infectivity caused by chemical or physical modification

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