ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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LPS (Lipopolysaccharide)

Molecule found in the outer cell walls of some bacteria that trigger the immune response resulting in fever. Also referred to as pyrogens or as endotoxins, though, strictly speaking, they are not endotoxins but predominant components of endotoxins produced by gram-negative bacteria. Common cause of pyrogenic reactions in parenteral products.

See also: Gram’s Stain

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