ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Lethal Dose-50% (LD50)

The dose of a chemical that will kill 50% of the test animals receiving it. The chemical may be given by mouth (oral), applied to the skin (dermal), or injected (parenteral). A given chemical will generally show different LD50 values depending on how it is given to the animals. It is a rough measure of acute toxicity.

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