ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Modified Atmosphere Packaging


1. Verb: To determine the relative positions of loci on a DNA molecule. Linkage mapping is done by estimating the recombination fraction between loci, from the genotypes of offspring of particular matings. The further apart two loci are on a chromosome, the greater will be the frequency of recombination between them up to a maximum of 50%, the situation observed when they are sufficiently far apart on a chromosome that recombinant gametes are as frequent as non-recombinant gametes, or when they are on different chromosomes. Physical mapping is usually performed by the use of in situ hybridization of cloned DNA fragments to metaphase chromosomes.

2. Noun: A diagram showing the relative positions of, and distances between, loci.

Publication Source: Food and Agricultural Organization of the United Nations (FAO)
Publication Date: 1999


Mouse Antibody Production

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