ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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A barrier, usually thin, that permits the passage only of particles up to a certain size or of special nature.

Publication Source: ISPE Baseline® Guide, Vol. 4: Water and Steam Systems (Second Edition)

Publication Date: 2011


A barrier, usually thin, that only permits the passage of particles of a certain size or special nature. Filtration membranes are thin polymer films that are permeable to water and other fluids:

1. Microporous membrane filters have measurable pore structures that physically remove particles or microorganisms larger than pore size.

2. Ultrafiltration membranes (sometimes called molecular sieves) also remove molecules larger than a specified molecular weight.

3. Reverse osmosis membranes are permeable to water molecules and very little else, rejecting even dissolved ions and endotoxins in water.

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