ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Monoclonal Antibody (mAb)

mAb generally refers to intact immunoglobulins often produced by hybridomas or other cell lines. Monoclonal Antibodies can be produced in large amounts and in pure form for diagnostic or therapeutic purposes. In the production of MAb, two different mammalian cell lines (cell cultures) are crossed by cell fusion (hybridoma technology).

Publication Source: ISPE Baseline® Guide, Vol. 6: Biopharmaceutical Manufacturing Facilities

Publication Date: 2004

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