ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Multiple Endocrine Neoplasia, Type 1 (MEN1)

A rare inherited disorder that affects the endocrine glands, which release hormones into the bloodstream. The disorder, also known as Wermer's syndrome, can cause multiple tumors in the parathyroid and pituitary glands and in the pancreas. These tumors are usually benign, but they can cause the glands to become overactive and secrete abnormal levels of hormones. Those abnormal secretions, in turn, can cause a variety of medical problems, ranging from kidney stones and fatigue to fertility problems and life-threatening ulcers.

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