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When applied to a diagnostic device or procedure, means one that does not by design or intention:
(1) Penetrate or pierce the skin or mucous membranes of the body, the ocular cavity, or the urethra, or
(2) Enter the ear beyond the external auditory canal, the nose beyond the anterior opening to the nasal cavity, the mouth beyond the pharynx, the anal canal beyond the rectum, or the vagina beyond the cervical bone. For purposes of this part, blood sampling that involves simple venipuncture is considered noninvasive, and the use of surplus samples of body fluids or tissues that are left over from samples taken for noninvestigational purposes is also considered noninvasive.
Publication Source: Committees on Human Research
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