ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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PVC (Polyvinyl Chloride)

The largest volume of the vinyl family of plastics. Overall it has excellent basic properties, may be easily processed and welded, and is exceptionally economical in cost. Homopolymers grades of PVC comprise over 80% of all PVC used, and contain 56.8% chlorine by weight. When the chlorine content is increased to about 67% its heat deflection temperature at 264 psi increases from 155°F (68°C) to 218°F (103°C). Because PVC is a thermally sensitive thermoplastic compounding ingredients such as heat stabilizers, lubricants, fillers, plasticizers, impact modifiers, pigments, and processing aids must be added to make it processible. PVC is prone to produce extractables during start-up in high purity water.

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