ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Parenteral Drug (LVP, SVP)

A parenteral drug is defined as one intended for injection through the skin or other external boundary tissue, rather than through the alimentary canal, so that active substances they contain are administered, using gravity or force, directly into a blood vessel, organ, tissue, or lesion. They are infused when administered intravenously (IV), or injected when administered intramuscularly (IM), or subcutaneously into the human body. A large volume parenteral (LVP) is a unit dose container of greater than 100 ml that is terminally sterilized by heat. Small volume parenteral (SVP) is a “catch-all” for all non-LVP parenterals products except biologicals. A small volume parenteral is a unit dose container of less than 100 ml

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