ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Penetrance

The percentage of individuals in population that show a particular phenotype among those capable of showing it, i.e., among those that have the genotype normally associated with that phenotype.

Publication Source: Food and Agricultural Organization of the United Nations (FAO)
Publication Date: 1999

Penetrance

The probability of a gene or genetic trait being expressed. “Complete” penetrance means the gene or genes for a trait are expressed in all the population who have the genes. “Incomplete” penetrance means the genetic trait is expressed in only part of the population. The percent penetrance also may change with the age range of the population.

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