ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Prion

A slow-acting virus-like proteinaceous infectious agent. Prions differ from viruses in that they are not known to contain either DNA or RNA. Suggested as a possible model for the causal agent of scrapie and related diseases.

Publication Source: ISPE Baseline® Guide, Vol. 6: Biopharmaceutical Manufacturing Facilities

Publication Date: 2004

See also: Bovine Spongiform Encephalopathy (BSE)

Prion

Believed to be the tiniest infectious particle consisting entirely of hydrophobic protein (no nucleic acid, DNA, or RNA), suggested as a possible model for the causal agent of scrapie and related diseases. Prion diseases in humans and animals are transmissible, neurodegenerative, genetic disorders that attack the cortex of the brain. (Term originally derived from proteinaceous infectious particles).

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