ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Pronucleus

The nucleus of a sperm or an egg prior to fertilization. Sperm and egg cells carry half the number of chromosomes of other nonreproductive cells. When the pronucleus of a sperm fuses with the pronucleus of an egg, their chromosomes combine and become part of a single nucleus in the resulting embryo, containing a full set of chromosomes.

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