ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Prophase

An early stage in nuclear division, characterized by the shortening and thickening of the chromosomes and their movement to the metaphase plate. It occurs between interphase and metaphase. During this phase, the centriole divides and the two daughter centrioles move apart. Each sister DNA strand from interphase replication becomes coiled, and the chromosome is longitudinally double except in the region of the centromere. Each partially separated chromosome is called a chromatid. The two chromatids of a chromosome are sister chromatids.

Publication Source: Food and Agricultural Organization of the United Nations (FAO)
Publication Date: 1999

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