ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Recalcification

A technique producing serum from anticoagulated plasma. Citrate and oxalate act as anticoagulants because they are Ca++ (Calcium Ion) chelating agents; Ca++ as calcium chloride is added in excess (1/40 Molar). Ca++ is a coagulation co-factor (catalyst) and promotes clot formation.

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