ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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The portion of a DNA molecule which is replicable from a single origin. Plasmids and the chromosomes of bacteria, phages and other viruses usually have a single origin of replication and, in these cases, the entire DNA molecule constitutes a single replicon. Eukaryotic chromosomes have multiple internal origins and thus contain several replicons. The word is often used in the sense of a DNA molecule capable of independent replication, e.g., “The shuttle vector pJDB219 is a replicon in both yeast and E. coli.”

Publication Source: Food and Agricultural Organization of the United Nations (FAO)
Publication Date: 1999

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