ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Silicon Dioxide (SiO2) and its hydrated forms classed as reactive and nonreactive. Generally, reactive silica is removed by the anion exchange resin. Reactive silica is only slightly ionized and is held lightly by the anion resin. It is for this reason that silica is the first thing to break through when the resin nears exhaustion. Non-reactive silica is generally considered particulate (colloidal) in nature.

Publication Source: ISPE Baseline® Guide, Vol. 4: Water and Steam Systems (Second Edition)

Publication Date: 2011


Silicon dioxide, SiO2, occurring naturally in crystalline, microcrystalline, and amorphous form; used to make glass and ceramics, and is used in pharmaceuticals. Silica gel is a jelly-like form of silicon dioxide that is widely used as a solid medium, as a dehumidifying and dehydrating agent, and in many chemical processes.

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