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A type II restriction endonuclease that binds (and subsequently cleaves) DNA at sites that contain a sequence of six nucleotide pairs that is uniquely recognized by that enzyme. Because any sequence of six bases occurs less frequently by chance than any sequence of four bases, six-base cutters cleave less frequently than do four-base cutters. Thus, six-base cutters create larger fragments than four-base cutters.
Publication Source: Food and Agricultural Organization of the United Nations (FAO)
Publication Date: 1999
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