ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Supercritical Fluid Extraction (SFE)

Supercritical Fluid Extraction (SFE) refers to a process in which a Supercritical Fluid (SF) is used as a solvent. At critical temperatures and pressures, SFs possess the properties of both the liquid and gas, with density values similar to those of liquids and flow properties similar to those of gases, and are thus labeled as fluids. The most widely used SF gas is carbon dioxide (CO2).



Publication Source: ISPE Good Practice Guide: Process Gases

Publication Date: 2011

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