ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Suppressor

Mutations in suppressor genes are able to overcome (suppress) the effects of mutations in other, unlinked, genes. A common, and very useful, kind of suppressor mutation occurs within the gene encoding a tRNA molecule and results in a change in the tRNA's anticodon. Such a mutant tRNA can reverse the effect of chain-terminating mutations, such as amber or ochre, in protein-encoding genes.

Publication Source: Food and Agricultural Organization of the United Nations (FAO)
Publication Date: 1999

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