ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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TSEs (Transmissible Spongiform Encephalopathies)

Chronic degenerative nervous diseases characterized by the accumulation of an abnormal isoform of a cellular glycoprotein known as PrP or prion protein. TSE diseases in animals include: bovine spongiform encephalopathy (BSE) in cattle, scrapie in sheep and goats, chronic wasting disease CWD) in cervids (deer and elk), transmissible mink encephalopathy (TME) in farmed mink, feline spongiform encephalopathy (FSE) in felidae (domestic cats and captive large cats), and spongiform encephalopathy of exotic ungulates in zoos.

In humans, spongiform encephalopathies include different forms of Creutzfeldt-Jakob Disease (CJD), kuru, Gertsmann-Straussler Syndrome (GSS) and fatal familial insommnia (FFI).

Publication Source: Food and Agricultural Organization of the United Nations (FAO)
Publication Date: 1999

See also: Animal Derived Ingredients (ADIs) Creutzfeldt-Jakob Disease

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