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A separation method that transfers components of one system (stream) into another. The stream the product is being extracted from crosses the stream that the product is being transferred to, multiple times.
Including ultrafiltration and most microfiltration systems, a separation method where the feed stream circulates back to the feed vessel, providing a tangential flow stream across the filter membrane.
Publication Source: ISPE Baseline® Guide, Vol. 6: Biopharmaceutical Manufacturing Facilities
Publication Date: 2004
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