ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Thrombin (Blood Coagulation Factor II)

An enzyme (the activated thrombogen) formed in the blood, after this is shed, that converts fibrinogen into fibrin for clot formation. It is formed from conjunction of prothrombin and calcium salts. It is also a sterile protein substance prepared from prothrombin of bovine origin through interaction with thromboplastin in the presence of calcium. Bovine thrombin is often used to aid production of serum from “salvage” plasma.

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