ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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Virus-like Particles

Particles that resemble retroviruses, yet lack infectivity, and usually are found in established lines of mammalian cells. Cell bank characterization seeks to determine whether viral activity is present, as a means of assessing risk. Not present in non-mammalian cells or cell lines.

Virus-Like Particles

(ICH Q5A (R1)) Structures visible by electron microscopy which morphologically appear to be related to known viruses.

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