ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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rRNA; Ribosomal RNA

The RNA molecules which are essential structural and functional components of ribosomes, the organelles responsible for protein synthesis. The different rRNA molecules are known by their sedimentation (Svedberg; symbol S) values. E. coli ribosomes contain one 16S rRNA molecule (1541 nucleotides long) in the same (small) sub-unit and a 23S rRNA (2904 nucleotides) and a 5S rRNA (120 nucleotides) in the large sub-unit. These three rRNA molecules are synthesized as part of a large precursor molecule which also contains the sequences of a number of tRNAs. Special processing enzymes cleave this large precursor to generate the functional moieties.

Publication Source: Food and Agricultural Organization of the United Nations (FAO)
Publication Date: 1999

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