Crystallization is well understood within the industry, but often it is difficult to control quality, yield and particle size distribution. This presentation reviews a number of batch and continuous crystallization Advanced Process Control (APC) and monitoring applications. In each example Model Predictive Control, fault detection and data quality monitoring techniques are combined to deliver a robust and fail-safe application. 1. Understand the benefits from the integration of process control and statistical techniques. 2. Appreciate that closed loop control must be delivered in a robust, failsafe environment.