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ISPE Glossary of Pharmaceutical and Biotechnology Terminology
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VPHP Microbiodecontamination
Technology used to decontaminate the exposed, internal surfaces within a sealed isolator and the exposed, external surfaces of materials and components placed within the sealed isolator. It consists of four distinctive phases:
1. Dehumidification – Lowers humidity and increases temperature
2. Conditioning – “Ramp-up” (VPHP) at or below saturation conditions
3. Sterilization – Steady-State (VPHP) at or below saturation conditions
4. Aeration – Reduces the VPHP to Safe Levels
See also: Isolator
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