Karen Rowland-Yeo, PhD

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Certara UK
Senior Vice President, Client and Regulatory Strategy
Karen Rowland-Yeo, PhD, is Senior Vice President, Client and Regulatory Strategy, at Certara UK Limited’s Simcyp Division. Prior to this, she was the Head of PBPK Consultancy Services at Simcyp, where she led a team of scientists engaged in consultancy projects relating to the application of PBPK modeling in drug development. She has worked directly with global regulators to gain acceptance of PBPK models, increasingly raising the bar in innovation and quality. She received her BSc Honours degree in physics at the University of Natal in South Africa in 1989 and her PhD in drug metabolism from the University of Sheffield in 1995. Prior to joining Simcyp in 2002, Karen held a five-year lectureship in clinical pharmacology and therapeutics at the University of Sheffield. Karen has authored more than 100 peer-reviewed articles ln the field of in vitro–in vivo extrapolation and PBPK modeling.

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Drug developers know that the odds of anyone compound demonstrating safety and efficacy for a disease and its affected populations are low. How can drug developers improve these odds and increase the efficiency and effectiveness of drug development? One useful tool is model-informed drug development (MIDD), which uses computer models to inform the design of clinical trials or to run...