ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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That is capable of filtering and large molecular weight organics out of the water. The particle size capability of ultrafiltration filters is to 0.005 microns.


Filtration under pressure similar to Reverse Osmosis. It consists of molecular sieves; membranes with pores small enough to remove colloids and large molecules. Rated in terms of nominal molecular weight cutoff. A 10,000 Dalton (molecular weight) UF membrane, for example, will remove bacterial pyrogens that are typically in the range of 20,000 Daltons.


Filter technology similar to reverse osmosis that is capable of filtering colloids and large molecular weight organics out of the water. The filter capability of ultrafiltration filters to 0.005 µm particle size. Ultrafiltration also will remove organic material down to about 1,000 10, 000 molecular weight.

Publication Source: ISPE Baseline® Guide, Vol. 4: Water and Steam Systems (Second Edition)

Publication Date: 2011

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